Primary HPV Screening Initiative

Primary HPV


Screening Initiative

About The Initiative

In 2020, the American Cancer Society released the updated Cervical Cancer Screening Guideline supporting the transition to primary HPV screening as the preferred method for cervical cancer screening. Primary HPV screening every 5 years has been shown to be a more effective approach to cervical cancer screening, but the transition from less effective options has been slow. In the fall of 2021, the American Cancer Society’s Primary HPV Screening Initiative set out to support the transition to primary HPV screening as the dominant screening approach in the United States. With nearly 100 expert volunteers on six workgroups and a Steering Committee, this initiative goes beyond guideline development and into guideline implementation.


The Initiative fills a key implementation gap in cervical cancer screening and management in the U.S. and is a crucial step in successful primary HPV screening adoption and guideline alignment across organizations. Achieving these objectives will provide a critical infrastructure to support continuing advancements in cervical cancer prevention, early detection, and elimination in the coming years.

Implementation in Action Workgroup Structure Image Final

Initiative Workgroup Structure


Resources are available for primary HPV screening implementation support.

“This initiative creates an opportunity to have all different walks of life come together to determine the best and most thoughtful way to address cervical cancer screening in the U.S.”

“Healthcare systems that have not yet transitioned to even offering primary HPV screening will benefit significantly from the initiative’s guidance about making the transition. Hopefully systems who already offer primary HPV screening will be inspired to promote uptake of this option based on the initiative’s resources.”

“This initiative is leading us into the future, increasing access, taking us out of the Pap smear and into a new paradigm; It is important to roll primary HPV screening out well and fast.”

“This initiative is of high value and influence.”

“I think the Insurance Workgroup outcomes will actually help providers to see how aware and supportive our colleagues on the payor side are of primary HPV screening.”

“This initiative has the potential to improve protection against cervical cancer while decreasing harms associated with cancer screening.”

The Primary HPV Screening Iniative Intersects with:

       Enduring Guidelines

Federal Collaborative on Cervical Cancer

Cancer Moonshot & President’s Cancer Panel

United States Preventive Services Task Force (USPSTF)

American Cancer Society (ACS)

American College of Obstetricians and Gynecologists (ACOG)

ACS National Roundtable on Cervical Cancer (ACS NRTCC)

American Society for Colposcopy and Cervical Pathology (ASCCP)

Health Systems across the U.S.

Synergy with the ACS NRTCC

The American Cancer Society National Roundtable on Cervical Cancer (ACS NRTCC) is focused on the elimination of cervical cancer by improving prevention, screening, treatment, and survivorship. The Primary HPV Screening Initiative addresses implementation challenges that face the future cervical cancer screening paradigm, thus positively contributing to the ACS NRTCC’s aim to improve screening. This initiative plays a key role in connecting screening guideline adoption to practice changes, resource development, and advances that the Roundtable will promote. This initiative has also established and fostered crucial relationships that will be carried forward on the Roundtable.

More Information About Primary HPV Screening

Check out our primary HPV tagged materials in the Resource Library and other resources below: